Airway Intervention Registry: Recurrent Respiratory Papillomatosis (AIR: RRP)

Recurrent Respiratory Papillomatosis (RRP) – sometimes referred to as Laryngeal Papillomatosis – is a condition caused by the Human Papilloma Virus (HPV). This results in warts in the airway which can make it difficult to breathe and speak.  RRP is a rare condition but is more common in young people.

The Question...

There is no cure for RRP, therefore patients usually require regular surgery to remove the warts. Although the most common treatment is repeated surgery, nobody knows what the best medical therapy is.

Our Research Study...

The aim of our study is to determine the most effective and safest treatments for RRP. 


Because RRP is so rare, we first needed to gather information from as many people with RRP as possible. We expanded the Airway Intervention Registry (AIR) to collect data from all RRP patients around the whole of the UK.  


The data collection stage of the study ended on 31 August 2022. We will now start to look at the data to help us to understand more about:  


  1. Identify which treatments work best for RRP.
  2. Reduce the number of treatments/hospital visits for RRP patients.
  3. Reduce the number of complications seen with RRP treatments.